ARRB2 and early-onset autosomal dominant Alzheimer disease: For instance, in brain, ARRB2 regulates Aβ generation and γ‐secretase activity in Alzheimer disease,11 and overexpression or activation of ARRB1, but not ARRB2, exerts neuroprotection through coordination of BECN‐1‐dependent autophagy in cerebral ischaemia.12