IDH2 and central nervous system cancer: While many other entities present as T1 isointense or hypointense and T2 hyperintense on MRI, a systematic review and meta-analysis of several studies evaluating the imaging characteristics of more than 2000 pathologically proven LGG showed that, compared to IDH wild-type gliomas, IDH-mutant gliomas tend to be located in the frontal lobes, have well-defined borders, higher apparent diffusion coefficient, are minimally invasive on diffuse tensor imaging sequences, and have a low relative cerebral blood volume [22].