This significantly increased SCW latency and restored SR Ca2+ content to near WT levels, suggesting that ROS scavenging can partially stabilize proarrhythmic RyR2 activity in CPVT VMs, similar to the effects of mitoTEMPO in rat VMS acutely challenged with caffeine (Figs. 1, 5a, b). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.