This is particularly evident in catecholaminergic polymorphic ventricular tachycardia (CPVT), a genetic disorder characterized by mutations in the RyR2 macromolecular complex, whereby ventricular tachycardia and fibrillation (VT/VF) often only present in patients after exercise or stress [30, 57]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.