Consistent with our previous results (Fig. 4) showing that posttranslational modulation of the FBW7-Mcl-1 axis was an underlying mechanism involved in macrophage-mediated colon cancer cell proliferation, the involvement of the FBW7-Mcl-1 axis in PDCs was also found in CM-treated macrophages (Fig. 5d). This evidence concerns the gene FBXW7 and malignant colon neoplasm.