A Venn diagram using (i) human IRDS genes27, (ii) orthologs of human IRDS genes, significantly downregulated in Stat1∆IECApcMin mouse tumors, and (iii) the 529 genes, identified to be co-expressed with Stat1 in the CRC TCGA dataset, revealed a substantial overlap. The gene discussed is STAT1; the disease is colorectal carcinoma.