Of interest is the observation that among three different aggressive cancer cell populations that produce micronuclei-inducing EVs (RAS-3, U373vIII and GSC83) the proteomes of these vesicles contain 19 common proteins, including molecules already implicated in genetic instability (CEP55)37 or calcium binding (ANXA1, ANXA2, PDCD6). Here, ANXA1 is linked to cancer.