ANXA2 and cancer: Of interest is the observation that among three different aggressive cancer cell populations that produce micronuclei-inducing EVs (RAS-3, U373vIII and GSC83) the proteomes of these vesicles contain 19 common proteins, including molecules already implicated in genetic instability (CEP55)37 or calcium binding (ANXA1, ANXA2, PDCD6).