As shown in Fig. 2d–f, the same PCA and DGEA methods applied to the whole cohort of cases revealed that the high expression of KI67, germinal center-associated genes (LMO2, BCL6, MAML3, S1PR2, and CD40), the CD68 and CD163 TAM markers, the GRZB and PRF cytotoxic markers, and the PD-L1 and PD-L2 immune checkpoints inhibitors were a common characteristic of aggressive lymphomas, regardless of the COO classification. The gene discussed is S1PR2; the disease is lymphoma.