MLKL and neoplasm: Further multivariate analysis revealed that p-MLKL expression [HR (95%CI) = 4.500 (1.885, 10.743)], N stage [HR (95%CI) = 8.919 (3.471, 22.917)] and tumor progression [HR (95%CI) = 4.502 (2.016, 10.054)] were independent risk factors for patient’s OS (Table 3), and p-MLKL expression [HR (95%CI) = 3.277 (1.534, 7.001)] and areca-nut [HR (95%CI) = 2.376 (1.258, 4.490)] consumption are independent risk factors for PFS (Table 4).