MLKL and neoplasm: S1), indicating that tumors with high MLKL expression may have a higher tendency to develop necroptosis. Correlation analyses show that high MLKL expression is correlated with the age under 60 years and alcohol consumption (Table 2). High p-MLKL expression is correlated with lower T stage, whereas high tumor necrotic level correlates with patients’ gender of male (Table 2). Importantly, both high level of p-MLKL and tumor necrosis correlate with lymph node metastasis and tumor progression (Table 2), indicating that necroptosis and necrosis may have potential influence on patient’s outcome.