MLKL and neoplasm: Univariate analysis showed that MLKL expression, p-MLKL expression, tumor necrosis, N stage, clinical stage, recurrence, cervical lymph node metastasis, and tumor progression are major risk factors for poor OS (Table 3), whereas p-MLKL expression, tumor necrosis, and areca-nut consumption are major risk factors for poor PFS (Table 4).