The Cancer Genome Atlas (TCGA) data for Spry1 were firstly obtained using the UALCAN web portal for gene expression analyses (http://ualcan.path.uab.edu/)31, which showed the messenger RNA (mRNA) expression of Spry1 was significantly elevated in metastatic CM respect to primary tumors (p value<0.01) (Fig. 1a). The gene discussed is SPRY1; the disease is cancer.