Given Spry2 was found to promote the growth of tumors harboring BRAF mutations27, we analyzed Spry1 expression in BRAFV600-mutant CM by using cBioPortal (http://www.cbioportal.org/)33, and overexpression of Spry1 mRNA was observed in 15% of these tumor types (Fig. 1c). This evidence concerns the gene SPRY2 and neoplasm.