The infection of PNCs with lentiviruses that express dCas9-KAT and a gRNA that recruits this chimeric protein to the most proximal KAT3 peak of Neurod2 (Fig. 8a, b) prevented the downregulation of NeuroD2 observed in dKAT3-KO neurons (Fig. 8c, d). Here, NEUROD2 is linked to infection.