Here, our studies identify ZFAS1 and its direct interaction target NOP58 (the core components of snoRNPs) as central to the master C/D box snoRNAs mediated 2′-O-methylation epigenetics modification network that is essential for CRC initiation and maintenance (see the proposed model in Fig. 8). The gene discussed is NOP58; the disease is colorectal carcinoma.