Our current studies further supported that NOP58 can directly interact with ZFAS1 to induce its function, and this complex then participates in C/D box SNORD12C and SNORD78 snoRNP complex assembly that is involved in 2′-O-Me of nucleotides at specific positions in rRNAs that ultimately contribute to CRC tumorigenesis. This evidence concerns the gene ZFAS1 and colorectal carcinoma.