To further clarify the function of snoRNAs in the context of ZFAS1-mediated regulation of CRC cell proliferation and the translation of target genes, we employed enrichment of co-expression analyses between SNORD12C/78 and mRNA expression to search the possible downstream target genes, including EIF4A3, LAMC2, MACC1, and CSE1L, responsible for regulating 2′-O-Me activities. The gene discussed is ZFAS1; the disease is colorectal carcinoma.