LAMC2 and colorectal carcinoma: Based on this, we identified a previously unrecognized signaling axis involving ZFAS1-NOP58-SNORD12C/78-EIF4A3/LAMC2 that functions in CRC tumorigenesis and our findings shed new light on our understanding of lncRNAs-snoRNPs-mediated rRNA 2′-O-methylations in CRC tumorigenesis and development.