Consistent with the results in CRC cells, the expression levels of ZFAS1 and NOP58 were elevated in the CRC tissues compared to the levels detected in the tumor-adjacent normal tissues (Fig. 4g), and a large positive linear correlation pattern was confirmed to exist between ZFAS1 and NOP58 within this cohort (Fig. S5c). The gene discussed is ZFAS1; the disease is neoplasm.