In CRC cells and tissues, ZFAS1 and its endogenous recruiting protein NOP58 are up-regulated, and this promotes the SNORD12C and SNORD78-mediated 28S rRNAs 2′-O-Me activities at specific sites to substantially increase the translation activation of downstream genes such as EIF4A3, LAMC2, and others. This evidence concerns the gene ZFAS1 and colorectal carcinoma.