ZCCHC4 and hepatocellular carcinoma: In patients with HCC, the expression of ZCCHC4 and m6A on 28S rRNA in cancer tissues was significantly increased as compared to that in the surrounding healthy tissues, whereas ZCCHC4 knockout in a xenograft mouse model eliminates m6A modification on 28S rRNA and then decreases global translation activity, which contributes to the inhibition of HCC cell proliferation and reduction in liver tumor size; thus, highlighting the essential role of m6A rRNA modification in mRNA translation and tumor progression [26].