In addition, in rare cases, the disease is inherited in an autosomal dominant early onset form caused by mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) genes, which might result in the alteration of Aβ production, leading to the apoptosis of the neurons and dementia [4,5]. The gene discussed is PSEN1; the disease is dementia.