We identified significant DGE among genes within the actin cytoskeleton signaling pathway between hypertensive AA and white women and we have validated the previously identified and hypertension-related miR-1253 as a novel regulator of WASP family Verprolin-homologous protein 2 WASF2 (also known as WAVE2), an integral member of the actin cytoskeleton pathway. The gene discussed is WASF2; the disease is hypertensive disorder.