We have demonstrated that IL-13Rα2 is overexpressed in numerous solid human cancers such as malignant glioma, squamous cell carcinoma of head and neck, Kaposi’s sarcoma, kidney cancer, adrenocortical cancer, and ovarian carcinoma [15,16] and that IL-13Rα2 can be efficiently targeted by a chimeric recombinant protein, which consists of IL-13 and truncated Pseudomonas exotoxin [17,18]. The gene discussed is IL13RA2; the disease is Kaposi's sarcoma.