Activation of RAGE by S100A4, S100A7, S100A8, S100A9, S100A14, S100B, and S100P was associated with upregulation of NF-κB that induced progression of different types of cancer including pancreatic, melanoma, breast, prostate, colon, neuroblastoma, and esophageal [74,97,106,108,113,114,115]. The gene discussed is NFKB1; the disease is cancer.