HMGB1 upregulated NF-κB expression in human pancreatic (BxPC-3) [74], hepatocarcinoma (HUH 7 and H22) [14,72], fibrosarcoma (HT1080) [11,75], non-small cell lung cancer (NSCLC) [76], HCC [77], and breast adenocarcinoma (MCF-7) cells [78]. This evidence concerns the gene HMGB1 and fibrosarcoma.