Binding of advanced glycation end products (AGEs), S100 proteins, high-mobility group box1 (HMGB1), amyloid β-peptide, lipopolysaccharides, β-sheet fibrils, advanced oxidation protein products, Mac-1, or phosphatidyl serine with RAGE directs the cancer cells toward survival and proliferation [6,7,8]. The gene discussed is HMGB1; the disease is cancer.