TP53 and cancer: A number of different studies demonstrated that induction of AGEs led to upregulation of phosphatidylinositide 3-kinase (PI3K) [22,33], protein kinase B (Akt) [22], NF-κB [13,42,43,44], and VEGF [21,24] and downregulation of p53 [23] in various cancer cell types (Table 1).