HMGB1 and fibrosarcoma: Using RAGE- or dominant-negative RAGE-expressing HT1080 human fibrosarcoma cells, papaverine suppressed RAGE-dependent HT1080 human fibrosarcoma cell proliferation, migration, and invasion in a dose-dependent manner through a significant inhibition of RAGE-dependent NF-κB driven by HMGB1 [11] (Figure 3).