CD73 is an ecto-5′-nucleotidase hydrolyzing extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate [53], whose over-expression has been reported in a variety of cancer cells and tumor patient biopsies, including gliomas, being associated with worse disease-free survival in GBM patients [54]. The gene discussed is NT5E; the disease is central nervous system cancer.