CD73 is an ecto-5′-nucleotidase hydrolyzing extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate [53], whose over-expression has been reported in a variety of cancer cells and tumor patient biopsies, including gliomas, being associated with worse disease-free survival in GBM patients [54]. This evidence concerns the gene NT5E and neoplasm.