The top five mostly enriched pathways were PI3K-Akt signaling pathway (hsa04151), viral carcinogenesis (hsa05203), cell cycle (hsa04110), MicroRNAs in cancer (hsa05206) and neurotrophin signaling pathway (hsa04722), indicating that PKs and PPBDs are synergistically involved in regulating these pathways (Figure 5E). The gene discussed is ARAF; the disease is cancer.