Overall, the presumed enhancement of TCR DP03chim expression level in comparison to that of TCR DP03WT increased reactivity to primary AML blasts and increased the HLA-DPB1*03:01 specific cytokine response against IFN-γ pretreated fibroblasts, particularly in CD4 T cells. Here, HLA-DPB1 is linked to acute myeloid leukemia.