From cultures co-incubating CD45RA-selected CD4 T cells and autologous dendritic cells expressing allogeneic HLA-DPA1*01:03/DPB1*03:01 upon RNA transfection, we were able to isolate an HLA-DPB1*03:01 specific CD4 T cell clone (i.e., clone 11G1) with reactivity to primary AML blasts [14], but most notably, there was no reactivity to primary fibroblasts even after HLA-DP induction upon IFN-γ pretreatment (Figure S4). Here, HLA-DPA1 is linked to acute myeloid leukemia.