Here, both TCR DP04chim redirected CD4 and CD8 T cells showed highly specific lysis of HLA-DPB1*04:01 expressing AML blasts (AML111, AML121, AML128), while sparing an HLA-DPB1*04:01 negative sample (AML110) (Figure 1C). The gene discussed is CD8A; the disease is acute myeloid leukemia.