Nevertheless, TCR DP03WT induced a robust recognition (i.e., IFN-γ secretion and cytolytic activity) of primary AML blasts (Figure 4B,C), but most importantly, lacked reactivity against fibroblasts when HLA-DP was physiologically induced by IFN-γ pretreatment (Figure 4A). Here, HLA-DPA1 is linked to acute myeloid leukemia.