NFE2L2 and cancer: Experimental work from Kovac et al. provided an explanation on how NRF2 might control compartment-specific redox balance since in a mouse model with graded NRF2 expression, this transcription factor was seen to regulate the mRNA levels of the cytosolic NOX2 and the mitochondrial NOX4 isoforms, despite the fact that it is unknown whether the same also occurs in cancer cells [91].