IGF1 and osteosarcoma: In this respect, by using a panel of prostate (DU145), osteosarcoma (U2OS) and breast (MCF-7) cancer cells, Riis et al. showed that NRF2 was a key player in downstream IGF-1 (insulin-like growth factor 1) signaling and required for the IGF-1-dependent induction of BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3), a regulator of cell apoptosis and mitophagy.