Other work showed that NRF2 overexpression and KEAP1 knockdown increased, while conversely the KEAP1 overexpression and NRF2 silencing reduced the expression level of G6PD and TKT in MCF-7 and MDA-MB-231 BCC both at the mRNA and protein levels. The gene discussed is KEAP1; the disease is skin basal cell carcinoma.