NFE2L2 and central nervous system cancer: In another study focused on A172 and U87 glioma cells, the hTERT (human telomerase) was found to act as a downstream effector of NRF2 activation required for the upregulation of G6PD and TKT genes, suggesting the existence of a regulatory loop that might be active in tumor specific contexts and mediate the metabolic adaptation of cancer cells [155].