In accordance, by using a model of human gastric cancer, Jiang et al. proved that the exposure of BGC-823 cells to the H2S donor DATS (diallyl trisulfide), was able to impair NRF2 and AKT activation inducing cell cycle arrest and cell demise through the modulation of BCL-2 family proteins involved in the initiation of mitochondrial-dependent apoptosis. Here, NFE2L2 is linked to gastric cancer.