For example, it has been shown that NRF2 can promote the ATF4 transcriptional activity in autophagy-deficient HCT116 CRC cells by disrupting its interaction with SIRT6 and promoting the expression of genes (SLC6A9, SLC36A4, SLC38A1 and SLC38A3) codying for AATs (aminoacid transporters) involved in the import of alanine, proline, tryptophan, glycin and glutamine. The gene discussed is NFE2L2; the disease is colorectal carcinoma.