NFE2L2 and hepatocellular carcinoma: Subsequently, the natural compound resveratrol was found to induce mitochondrial biogenesis in Lipopolysaccharides (LPS)-treated HepG2 hepatocellular cancer cells (HCC) through the sequential production of Nitric and Carbon oxide, the latter event requiring AKT phosphorylation and NRF2-dependent HO-1 induction [70].