Earlier studies have shown that NRF2 can induce the expression of the iron-storage protein ferritin H in murine Hepa1–6 hepatoma, human NIH3T3 fibroblasts and HepG2 HCC cells treated with dithiolethiones [134], while NRF2 was recently found to constitutively bind the AREs of the ferritin H gene in HepG2 cells, probably to ensure its basal expression [135]. The gene discussed is FTH1; the disease is hepatocellular carcinoma.