Indeed, Shan et al. proved that the administration of diallyl disulfide (DADS), a slow H2S donor, was able to dose-dependently attenuate the incidence of skin cancer in a mouse model of chemically-induced carcinogenesis, by promoting p21/NRF2 interaction and the upregulation of several antioxidant enzymes due to enhanced NRF2 nuclear accumulation [129]. Here, NFE2L2 is linked to skin cancer.