ATF4 and non-small cell lung carcinoma: Interestingly, by using NSCLC cells subdued to nutrient stress, Gwinn et al. found that the activation of the KRAS/AKT/NRF2/ATF4 axis enhanced the expression of the SLC1A5, SLC38A2, SLC7A5, SLC7A1 and SLC7A11 genes, respectively codying for the amino acid transporters ASCT2, SNAT2, CAT1 and LAT2 involved in the uptake of neutral, branched-chain and aromatic aminoacids.