It is becoming increasingly clear that pro-oncogenic alterations of the NRF2/KEAP1 pathway play a crucial role in driving the metabolic rewiring of cancer cells, orchestrating a multi-layered transcriptional program that ultimately provides the precursor molecules to support cancer cell proliferation and the reducing equivalents to cope with the augmented bulk of intracellular ROS resulting from the malignant progression. This evidence concerns the gene KEAP1 and cancer.