As evidenced by Campbell et al., the list of NRF2 target genes codying for proteins involved in iron and heme metabolism, including FTL, FTH1, AMBP, ABCB6, FECH, HRG-1 (SLC48A1) and TBXAS1, is constantly expanding but their functional role in cancer-specific contexts still needs to be fully elucidated [144]. This evidence concerns the gene SLC48A1 and cancer.