Further investigations revealed that NRF2 silencing suppressed both xCT expression and glutamate export in Hs578T and MDAMB-231 BCC, conferring resistance to glucose deprivation due to enhanced mitochondrial respiration, while DMF-dependent NRF2 induction reverted this phenotype and promoted glucose addiction [105]. The gene discussed is SLC7A11; the disease is skin basal cell carcinoma.