KEAP1 and esophageal squamous cell carcinoma: More recently, NRF2 was seen to enhance the levels of the glutamine transporter coded by the SLC1A4 gene and other metabolic enzymes in KEAP1-deficient esophageal squamous cancer cells (ESCC) of different origin inducing metabolic rewiring, while its genetic silencing or glycolysis inhibition decreased the ATP levels and the proliferation of human ESCC with high NRF2 levels [113].