NFE2L2 and hepatocellular carcinoma: Notably, another work suggested that NRF2 could also induce the expression of TCA cycle enzymes involved in NADPH synthesis, such as ME1 and IDH1 [153,160] or that of the folate cycle enzyme MTHFDL1 (methylenetetrahydrofolate dehydrogenase 1-like), that has been shown to enhance cell proliferation and sorafenib resistance in HCC both in vitro and in vivo through metabolic rewiring and increased NADPH generation [161], in agreement with other data [162].