NFE2L2 and non-small cell lung carcinoma: In a seminal study from De Nicola et al., metabolic tracing and transcriptional profiling on a panel of NSCLC cell lines revealed that NRF2 controlled the transcription of PHGDH, PSAT1 and SHMT2, the key enzymes involved in serine/glycine biosynthesis through ATF4 activation.