NFE2L2 and non-small cell lung carcinoma: Lastly, in a recent study it was shown that the triterpenes ursolic and oleanolic acids could induce mitophagy in A549 non-small cell lung cancer (NSCLC) cells by promoting PINK1 upregulation and its recruitment to the outer mitochondrial membrane, presumably in response to the increased NRF2 expression caused by ROS overproduction, despite the lack of mechanistic evidence that precludes further speculation [76].