For instance, by exposing SH-SY5Y neuroblastoma (NB) cells to oxidative stress (OS) conditions, Murata et al. showed that NRF2 could directly enhance the transcription of PINK1 mRNA (PTEN-induced kinase 1), an essential regulator of mitochondrial quality control that promoted cell survival by mediating the recognition of damaged mitochondria [74]. This evidence concerns the gene NFE2L2 and neuroblastoma.