Up-to-date radionuclide-, fluorescence-, nanoparticle-labeled mHsp70-targeted tools (including full recombinant Hsp70, monoclonal anti-Hsp70 antibodies, antibody Fab fragments, tumor penetrating peptide (TPP), granzyme B, and anticalines) have been successfully employed for visualization (MRI, PET, epifluorescence) and therapy in preclinical studies (Table 1). The gene discussed is HSPA1A; the disease is neoplasm.