In addition, although miR-148a (AUC of 0.860) alone was significantly superior to AFP (AUC of 0.665), the combination of miR-122, miR-148a, and AFP exhibited a higher diagnostic power in discriminating early HCC from liver cirrhosis in humans, with an AUC of 0.947 [88]. The gene discussed is AFP; the disease is cirrhosis of liver.