Last but not least, a panel of miR-122, miR-885-5p, and miR-29b, associated with AFP testing, was shown to exhibit high diagnostic accuracy for the early detection of HCC in a normal population, whereas combining miR-122, miR-885-5p, miR-221, and miR-22 with AFP allowed for the accurate diagnosis of early HCC in cirrhosis [139]. This evidence concerns the gene AFP and hepatocellular carcinoma.