APC and hepatocellular carcinoma: Alterations in cfDNA methylation, associated with the initiation and progression of HCC, have been described for many other genes, including p15, p16, APC, SPINT2, SFRP1, p16INK4a, TFPI2, GSTP1, SEPT9, VIM, and FBLN1, as well as in CpGs sites [14,121,122,123].