Alterations in cfDNA methylation, associated with the initiation and progression of HCC, have been described for many other genes, including p15, p16, APC, SPINT2, SFRP1, p16INK4a, TFPI2, GSTP1, SEPT9, VIM, and FBLN1, as well as in CpGs sites [14,121,122,123]. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.