In addition, Julich-Haertel et al. showed that AnnexinV, EpCAM, ASGPR1 and CD133 simultaneously positive EVs could be detected in HCC and CCA, being further able to differentiate these two types of liver tumors from other cancer types, as well as patients with cirrhosis and healthy individuals, with a sensitivity of 81% and positive predictive value (PPV) of 73% (cirrhosis vs. HCC) [84]. The gene discussed is PROM1; the disease is hepatocellular carcinoma.