AFP and hepatocellular carcinoma: Similarly, the combination of miR-92-3p, miR-107, and miR-3126-5p with AFP was highly effective in differentiating patients with early stage HCC (AUC of 0.988) and patients with a low level of AFP in HCC (AUC of 0.989) from healthy individuals, even more so than the three miRNAs panel alone [144].