Transgenic mice with the hepatocyte-specific expression of the oncogene URI (unconventional prefoldin RBP5 interaction) developed DNA damage because of the inhibition of enzymes regulating NAD metabolism leading to HCC, and when fed a high fat diet (HFD), these mice developed NASH and, subsequently, HCC, which was associated with T helper 17 (Th17) lymphocyte-mediated inflammation [24,25]. This evidence concerns the gene RBP5 and hepatocellular carcinoma.