On the contrary, SIRT1 transgenic mice were protected from HFD-induced steatosis with the induction of antioxidant proteins—superoxide dismutase 2 (SOD2/MnSOD) and nuclear factor, erythroid 2 like 1 (NFE2L1/NRF1)—and inhibition of NF-κB activity, resulting in the decreased production of pro-inflammatory cytokines, and they were also protected from DEN-induced DNA damage and DEN/HFD-induced hepatocarcinogenesis [70,71]. Here, SIRT1 is linked to steatosis.