It was documented that HDAC3 is downregulated in mice, and further analysis of hepatocyte-specific HDAC3 knockout mouse revealed the development of spontaneous HCC resulting from increased DNA damage because of the hyperacetylation and consequent demethylation of H3K9, resulting in the increased transcription of genes regulating oncogenic signaling pathways [68]. Here, HDAC3 is linked to hepatocellular carcinoma.