Knocking out betaine-homocysteine S-methyltransferase (BHMT), which catalyzes the conversion of homocysteine to methionine, was associated with a decrease in hepatic SAMe and corresponding increase in S-adenosyl-L-homocysteine, and led to the development of NASH and HCC [60]. The gene discussed is BHMT; the disease is metabolic dysfunction-associated steatohepatitis.