GNMT expression is significantly downregulated in the livers of cirrhotic and HCC patients, and GNMT knockout mouse developed NASH and HCC, which was associated with the activation of the Ras and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways because of the hypermethylation of the promoters of Ras association domain family member 1 (RASSF1) and suppressor of cytokine signaling 2 (SOCS2), which inhibit these pathways, respectively [54]. This evidence concerns the gene SOCS2 and hepatocellular carcinoma.