SETX and cerebellar ataxia: Senataxin (SETX) gene mutations are known to cause ataxia with oculomotor apraxia type 2 (an autosomal recessive cerebellar ataxia with onset between age three and 30 years after initial normal development, axonal sensorimotor neuropathy, oculomotor apraxia, cerebellar atrophy, and elevated serum concentration of α-fetoprotein) and juvenile amyotrophic lateral sclerosis type 4 (an autosomal dominant amyotrophic lateral sclerosis with mean age of onset at 17 years, slowly progressive distal amyotrophy, pyramidal signs, normal sensory examination, and lack of bulbar involvement).