PRRT2 mutations were first linked to PKD in 2011 [24], and this gene was later found to cause also benign familial infantile seizures (BFIS) and infantile convulsions with choreoathetosis (ICCA) syndrome [1], leading to consider PRRT2-related paroxysmal disorders as a continuous phenotypic spectrum [161]. The gene discussed is PRRT2; the disease is benign familial infantile epilepsy.