In this study, overexpression of IGFBP-3 showed that IGFBP-3 binding to GRP78 results in the disruption of the GRP78-caspase-7 complex, which, thereby, activates caspase-7, and, subsequently, induces apoptosis in anti-estrogen-resistant breast cancer cells. Here, IGFBP3 is linked to breast carcinoma.