Given the high significance of IGFBP-3 gene expression on survival outcome in glioma (FDR = 1.51∙10−32 (HR = 4.39)), it was unsurprising that IGFBP-3 expression affected survival in nearly all glioma subgroups (FDR < 2.90∙10−2), with lower expression being associated with better survival outcome. The gene discussed is IGFBP3; the disease is central nervous system cancer.