Moreover, several studies demonstrated that the loss of IGFBP-3 expression by DNA methylation is linked to tumorigenesis and cancer progression as well as intrinsic and/or acquired resistance to radiotherapy and chemo-drugs such as cisplatin in many different types of cancer including lung, colon, and ovarian cancers [62,63,64,65,66,67,68,69]. Here, IGFBP3 is linked to cancer.