IGFBP3 and lung cancer: Since GalNAc-T14 has been shown to be associated with poor recurrence-free survival and promote cell migration and invasion as well as metastasis through the Wnt signaling in lung cancer [92], IGFBP-3 may interfere with pro-tumorigenic and pro-metastatic GalNAc-T14 signaling by complexing with GalNAc-T14 in certain types of cancer including lung cancer.