Although overexpression of IGFBP-3 induced expression of Cyclin E, CDK2, and p-ERK1/2, and overexpression of GalNAc-T14 inhibited these IGFBP-3 effects in glioblastoma cells, no evidence was presented whether direct binding of these two proteins is involved in observed biological outcomes [93]. Here, IGFBP3 is linked to glioblastoma.