From the 17 cancer-related related genes, three (CHEK2, ERCC3, and MSH2) directly interact with MUS81 and four (PRKAR1A, MLH1, MUTYH, POLE) indirectly interact with MUS81 via CHEK2, ERCC3, and MSH2 (Figure 2). The gene discussed is MUS81; the disease is cancer.