It has also been proved through many human studies and animal models that IUGR is related to hypoxemia, affected placental transport capacity, alteration on vasculogenesis and angiogenesis, dysregulation of insulin-like growth factors activity, increased levels of apoptosis, autophagy, and glucocorticoid actions, as well as an increased in inflammatory response and imbalance of the immune system [6,44,45,46]. The gene discussed is INS; the disease is fetal growth restriction.