These results are in accordance with previous findings reported by Rupasri et al., on a glucocorticoid-induced IUGR rat model, where it was demonstrated that placental insufficiency is associated with dysregulated placental PRL family gene expression and down-regulation of the IGF-II/Akt signaling pathway, which ultimately increases placental apoptosis [75]. The gene discussed is PRL; the disease is fetal growth restriction.