Djuzenova et al., Del Alcazar et al., Kuger et al. (2), Wang et al., Mukherjee et al. and Cerniglia et al., all demonstrated that dual PI3K/mTOR inhibitors successfully radiosensitise GBM cell lines in vitro [49,74,90,91,92,93]. This evidence concerns the gene MTOR and glioblastoma.