Although, Napepld∆Hep mice exhibited an exacerbated fat mass accumulation, they did not develop a worsened glucose intolerance nor higher plasma insulin level compared to WT during the OGTT suggesting that the potential effect of NAPE-PLD on insulin level might be hidden by the diet itself, which could be the main driver (Figure S4A–E). The gene discussed is GPLD1; the disease is Glucose intolerance.