CTNNB1 and hepatocellular carcinoma: The steatohepatitic subtype of HCC is characterized by activation of the interleukin (IL)-6/JAK/STAT pathway with wild-type CTNNB1, TERT, and TP53. Interestingly, such phenotypic features are closely linked to the G1–G6 subgroups proposed by Boyault et al. with the association of progenitor phenotype to G1, macrotrabecular massive subtype and macrovascular invasion to G3, steatohepatitic subtype to G4, and cholestasis and lack of inflammatory infiltrates to G5 and G6 (Figure 1) [9].