Guichard et al. classified mutations of HCC based on the signaling pathway involved, such as Wnt/β-catenin, p53/cell cycle control, chromatin remodeling, phosphoinositide 3-kinase (PI3K)/Ras signaling, and oxidative stress and endoplasmic reticulum stress pathway [16]. Here, PIK3CA is linked to hepatocellular carcinoma.