For example, expression of PD-1, TIM-3, LAG-3, and CTLA4 is significantly higher on CD8+ and CD4+ T-cells in HCC tissue than those in non-tumor tissues or peripheral blood, and dendric cells (DCs), monocytes, and B cells in tumors express ligands for these receptors [45]. Here, LAG3 is linked to hepatocellular carcinoma.