A decrease in repression-associated H3K27me3 (and an increased activity of KDM6A/UTX) is a key feature of the global chromatin reconfiguration that takes place not only in somatic cells during physiological aging but also in the prematurely aging cells from patients with Hutchinson-Gilford progeria or Werner syndrome [63,116,117]. Here, KDM6A is linked to Hutchinson-Gilford progeria syndrome.