TARDBP and amyotrophic lateral sclerosis: A multitude of phenotypes could be observed by this including aggregation of transactive response DNA binding protein 43 kDA (TDP-43) in the case of ALS-frontotemporal dementia (FTLD)-CSF [8], neurofilament abnormalities [9], gliosis [10], endoplasmic reticulum (ER)-stress [6], mitochondrial dysfunction [11] and Golgi fragmentation [6,12].