During the development of liver fibrosis in a murine model of schistosomiasis, He et al. found that by targeting Signal Transducer And Activator Of Transcription 1 (STAT1), miR-146 suppressed the interferon (IFN)-γ-induced differentiation of macrophages to M1 cells [38]. The gene discussed is IFNG; the disease is schistosomiasis.