TMC4 and liver disorder: The MBOAT7 variant, originally reported as intergenic variant between MBOAT7 and Transmembrane Channel Like 4 (TMC4), is located in the 3’UTR of the MBOAT7 gene and results in its decreased expression level, which consequently induces liver disease by altering phosphatidylinositol remodeling [8] and by triggering a novel non-canonical hepatic triglyceride synthesis pathway fuelled by phospholipid turnover [24].