In support of IL-10 tumor suppressor action, several studies observed that IL-10 was able to induce AML blasts apoptosis in vitro probably through the inhibition of proinflammatory cytokines production, such as IL-1α, IL-1β, IL-6, GM-CSF and TNF-α [110,111,112]. The gene discussed is CSF2; the disease is acute myeloid leukemia.