Finally, activating mutations of the Tyrosine phosphatase SHP-2 (encoded by Ptpn11 gene) in MSCs and osteoprogenitors, already found in Noonan syndrome and associated with an increased risk progression to leukemia, induce juvenile myelomonocytic leukemia-like myeloproliferative neoplasm in mice through the overproduction of chemokine CCL3 [179]. The gene discussed is CCL3; the disease is Noonan syndrome.