AHR and renal carcinoma: Considering that AF exhibits noteworthy evidence of antitumor activity in vitro and in vivo against neoplastic cells of renal origin, inducing CYP1A1, and the covalent binding of the AF-reactive intermediates and apoptosis, our research group evaluated the role of AhR, the main transcriptional regulator of CYP1A1, in the antiproliferative effects of AF in human renal cancer cells.