CD274 and neoplasm: Monoclonal antibodies directed against programmed death receptor-1 (PD-1), e.g., nivolumab and pembrolizumab, and its ligand (PD-L1) Avelumab, inhibit the immunosuppressive co-signals mediated by PD-1/PD-L1 interaction, enhancing the anti-tumor activity of the T-cells [12].