Preclinically, the antitumor benzothiazoles 5F 203 and Phortress (Figure 2) evoked potent antiproliferative activity in breast and ovarian tumor models, inducing CYP1A1 expression and generating DNA adducts, which are converted to lethal strand breaks in sensitive cell lines and xenografts only [26,32]. Here, CYP1A1 is linked to ovarian neoplasm.