Considering that AF exhibits noteworthy evidence of antitumor activity in vitro and in vivo against neoplastic cells of renal origin, inducing CYP1A1, and the covalent binding of the AF-reactive intermediates and apoptosis, our research group evaluated the role of AhR, the main transcriptional regulator of CYP1A1, in the antiproliferative effects of AF in human renal cancer cells. This evidence concerns the gene CYP1A1 and renal carcinoma.