Additionally, we note that the sensitivity predicted by the PP value in the early stage of HCC was higher than that predicted by AFP, and the PP value tended to decrease from LC to HCC of stage I then to HCC of stage II, which suggests that anti-TAA autoantibodies might occur very early in the development of HCC and may be used as serological biomarkers in the early screening of HCC. Here, AFP is linked to hepatocellular carcinoma.