CHRNA4 and channelopathy: Autosomal dominant sleep-related hypermotor epilepsy (ADSHE), the first identified as a distinct familial idiopathic epilepsy (previously, ADNFLE: autosomal dominant nocturnal frontal lobe epilepsy) in 1994 [2,3], was reported as a channelopathy caused by a mutation in the CHRNA4 gene, which encodes α4 subunit of nicotinic acetylcholine receptor (nAChR).