There have been some systematic reviews of diabetes management with dietary supplements, providing limited evidence on the effects of coccinia indica, trigonella foenum, American ginseng, aloe vera, chromium, vanadium, ginger, curcuminoid and cinnamon supplements for insulin resistance, glycaemic and lipid control.[20,21] Some of these supplements are still useful in prediabetic individuals. This evidence concerns the gene INS and diabetes mellitus.