An increased frequency of toxoplasma encephalitis has been reported in patients with AIDS, especially in those with CD4+ T cell counts of <100 cells/μL.[6] The prevalence of co-infection with Toxoplasma gondii and HIV ranges from 25.1% to 60.7% in different countries,[4] clearly indicating that co-infection with Toxoplasma gondii and HIV continues to be a substantial global public health concern.[7]. This evidence concerns the gene CD4 and cerebral toxoplasmosis.