PRNP and Creutzfeldt Jacob disease: Patient 4 had bilateral hyperintensity lesions in thalamus on DW-MRI (Appendix Figure 1, panel B), no PSWCs on EEG, methionine homozygosity at codon 129 of PRNP, gait disturbance as an initial symptom, and long disease duration (19 months), similar to the features of the patients with plaque-type dCJD, suggesting that this patient had CJD-MMiK.