INS and Large for gestational age: In seven studies including 1,587 participants [32,35,36,50,53,58,59], neonates exposed to glyburide had increased rates of macrosomia compared to insulin-exposed neonates (OR 1.38, 95% CI 1.01 to 1.89; I2 = 31%, p = 0.04) (Fig 4A).