On univariate analysis, time-updated CD4 cell count of lower than 200 (RR: 12.22, 95%CI 4.52–33.05), CD4 cell count between 200 and 500 (RR: 5.99, 95% CI: 2.21–16.18), time-updated CD8 cell count lower than 500 (RR: 2.84, 95% CI: 1.14–7.06), time-updated CD4/CD8 ratio of less than 0.30 (RR: 7.77, 95%CI: 3.38–17.86), and lack of normalization of CD4 T-cell count (RR: 6.49, 95% CI: 1.96–21.49) were associated with increased risk of developing TB. The gene discussed is CD8A; the disease is tuberculosis.