CDK4 and hepatocellular carcinoma: 3a). Similarly, overexpression of miR‐383 led to a great loss of invasive ability of HepG2 cells (p < .05; Figure. 3b). These results showed that overexpression of miR‐383 inhibited cell migration and invasion in HCC cells. Furthermore, western blot of proliferation related protein, CDK4 and CDK6, and migration related proteins, MMP2 and MMP9, displayed reduced expression in HepG2 cells transfected with miR‐383 mimics (Figure 3c), verifying the function of miR‐383 in proliferation and migration of HepG2 cells at molecular level.