Till date, nearly 70 mutations have been identified in APOE associated with LPG, dysbetalipoproteinemia, hypertriglyceridemia and Alzheimer's disease, etc. The first mutation associated with LPG in APOE was APOE‐Sendai reported in Japan (Saito et al., 1989). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.