MET significantly attenuated the increase in AF duration (13.06 ± 5.4 s to 6.82 ± 2.64s, P < .01); however, AF duration in the RAP + MET group remained higher than that in the sham‐operated group (P = .03) (Figure 1D). This evidence concerns the gene LRPAP1 and atrial fibrillation.