Similar to Tfh-like cells, which were found in SLE and other autoimmune diseases (Horiuchi and Ueno, 2018; Hutloff, 2018; Rao, 2018; Vu Van et al., 2016), the super-functional subset delivers effective B-cell help for IgG production in an IL-21- and CD40L-dependent manner. This evidence concerns the gene IL21 and autoimmune disease.