Examination of cluster-specific marker genes showed that tumor ECs expressed a unique set of genes such as Col18a1 and Aplnr, but also shared a number of expressed genes with venous ECs, especially with PV, such as Cd63, Ehd4, and Cd200 (Fig. 2c and d, Supplementary Fig. 3a, and Supplementary Table 2). The gene discussed is EHD4; the disease is neoplasm.