After the adjustment for confounding factors, patients with a higher circulating ANGPTL3 level had a higher OR for CAD (OR = 1.74/10 ng ANGPTL3, 95% CI, 1.29–2.35; P < 0.001), indicating that ANGPTL3 level is an independent risk factor for CAD. This evidence concerns the gene ANGPTL3 and coronary artery disorder.