In light of this contradictory evidence, researchers have successfully developed an orally bioavailable adiponectin mimetic small molecule drug, AdipoRon, that strongly binds to adiponectin receptors (AdipoR1 and AdipoR2) and ameliorates diabetic conditions while extending lifespan in diabetic db/db mice placed on high‐fat diet.40 Gene therapy for adiponectin supplementation has also been extensively studied for diabetes treatment. This evidence concerns the gene ADIPOQ and diabetes mellitus.