Likewise, the adipocytes in obese individuals secrete several adipokines implicated in insulin resistance such as resistin, retinol‐binding protein 4 (RBP‐4), MCP‐1, progranulin, chemerin, and angiopoietin‐like protein 2 (ANGPTL2).9, 12 Similar pathophysiology is observed in other key insulin target organs such as muscles and liver. This evidence concerns the gene GRN and Insulin resistance.